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2014 ; 17
(6
): 756-63
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Genome-scale neurogenetics: methodology and meaning
#MMPMID24866041
McCarroll SA
; Feng G
; Hyman SE
Nat Neurosci
2014[Jun]; 17
(6
): 756-63
PMID24866041
show ga
Genetic analysis is currently offering glimpses into molecular mechanisms
underlying such neuropsychiatric disorders as schizophrenia, bipolar disorder and
autism. After years of frustration, success in identifying disease-associated DNA
sequence variation has followed from new genomic technologies, new genome data
resources, and global collaborations that could achieve the scale necessary to
find the genes underlying highly polygenic disorders. Here we describe early
results from genome-scale studies of large numbers of subjects and the emerging
significance of these results for neurobiology.
|*Genomics
[MESH]
|Animals
[MESH]
|Genetic Predisposition to Disease/genetics
[MESH]
|Genome-Wide Association Study/methods/trends
[MESH]
|Humans
[MESH]
|Mental Disorders/diagnosis/*genetics
[MESH]
|Nervous System Diseases/diagnosis/*genetics
[MESH]