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10.3390/ijms161023604 http://scihub22266oqcxt.onion/10.3390/ijms161023604 C4632716!4632716 !26437403     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26437403 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2015 ; 16 (10 ): 23604-14 Nephropedia Template TP {{tp|p=26437403 |t=2015. Genome Editing Using Mammalian Haploid Cells |pdf=|usr=}}{{26437403 }} gab.com Text Genome Editing Using Mammalian Haploid Cells JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26437403 #FOAvip Haploid cells are useful for studying gene functions because disruption of a single allele can cause loss-of-function phenotypes. Recent success in generating haploid embryonic stem cells (ESCs) in mice, rats, and monkeys provides a new platform for simple genetic manipulation of the mammalian genome. Use of haploid ESCs enhances the genome-editing potential of the CRISPR/Cas system. For example, CRISPR/Cas was used in haploid ESCs to generate multiple knockouts and large deletions at high efficiency. In addition, genome-wide screening is facilitated by haploid cell lines containing gene knockout libraries. Twit Text FOAVip Genome Editing Using Mammalian Haploid Cells ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26437403 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26437403 #FOAvip English Wikipedia <ref>{{Cite pmid|26437403 }}</ref> Genome Editing Using Mammalian Haploid Cells #MMPMID26437403 Horii T ; Hatada I Int J Mol Sci 2015[Oct]; 16 (10 ): 23604-14 PMID26437403 show ga Haploid cells are useful for studying gene functions because disruption of a single allele can cause loss-of-function phenotypes. Recent success in generating haploid embryonic stem cells (ESCs) in mice, rats, and monkeys provides a new platform for simple genetic manipulation of the mammalian genome. Use of haploid ESCs enhances the genome-editing potential of the CRISPR/Cas system. For example, CRISPR/Cas was used in haploid ESCs to generate multiple knockouts and large deletions at high efficiency. In addition, genome-wide screening is facilitated by haploid cell lines containing gene knockout libraries. |*Genome [MESH] |*Haploidy [MESH] |Animals [MESH] |Cell Line [MESH] |Embryonic Stem Cells/metabolism [MESH] |Humans [MESH] |Mammals/*genetics [MESH]Genome Editing Using Mammalian Haploid Cells (epmc).pdf DeepDyve Pubget Overpricing