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10.1016/j.molmed.2015.02.009 http://scihub22266oqcxt.onion/10.1016/j.molmed.2015.02.009 C4573548!4573548 !25883069     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25883069 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Mol+Med 2015 ; 21 (5 ): 285-94 Nephropedia Template TP {{tp|p=25883069 |t=2015. Genetics and the placebo effect: the placebome |pdf=|usr=}}{{25883069 }} gab.com Text Genetics and the placebo effect: the placebome JO: Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25883069 #FOAvip Placebos are indispensable controls in randomized clinical trials (RCTs), and placebo responses significantly contribute to routine clinical outcomes. Recent neurophysiological studies reveal neurotransmitter pathways that mediate placebo effects. Evidence that genetic variations in these pathways can modify placebo effects raises the possibility of using genetic screening to identify placebo responders and thereby increase RCT efficacy and improve therapeutic care. Furthermore, the possibility of interaction between placebo and drug molecular pathways warrants consideration in RCT design. The study of genomic effects on placebo response, 'the placebome', is in its infancy. Here, we review evidence from placebo studies and RCTs to identify putative genes in the placebome, examine evidence for placebo-drug interactions, and discuss implications for RCTs and clinical care. Twit Text FOAVip Genetics and the placebo effect: the placebome ????Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25883069 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25883069 #FOAvip English Wikipedia <ref>{{Cite pmid|25883069 }}</ref> Genetics and the placebo effect: the placebome #MMPMID25883069 Hall KT ; Loscalzo J ; Kaptchuk TJ Trends Mol Med 2015[May]; 21 (5 ): 285-94 PMID25883069 show ga Placebos are indispensable controls in randomized clinical trials (RCTs), and placebo responses significantly contribute to routine clinical outcomes. Recent neurophysiological studies reveal neurotransmitter pathways that mediate placebo effects. Evidence that genetic variations in these pathways can modify placebo effects raises the possibility of using genetic screening to identify placebo responders and thereby increase RCT efficacy and improve therapeutic care. Furthermore, the possibility of interaction between placebo and drug molecular pathways warrants consideration in RCT design. The study of genomic effects on placebo response, 'the placebome', is in its infancy. Here, we review evidence from placebo studies and RCTs to identify putative genes in the placebome, examine evidence for placebo-drug interactions, and discuss implications for RCTs and clinical care. |*Placebo Effect [MESH] |Clinical Trials as Topic [MESH] |Genetic Variation/*genetics [MESH] |Genetics [MESH] |Humans [MESH] |Neurotransmitter Agents/genetics [MESH] |Randomized Controlled Trials as Topic [MESH]Genetics and the placebo effect: the placebome (epmc).pdf DeepDyve Pubget Overpricing