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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Pediatr+Genet
2013 ; 2
(1
): 9-20
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Genetics and non-syndromic facial growth
#MMPMID27625834
Hartsfield JK
; Morford LA
; Otero LM
; Fardo DW
J Pediatr Genet
2013[Mar]; 2
(1
): 9-20
PMID27625834
show ga
Just as pediatricians and endocrinologists are interested in understanding
statural growth patterns and the prediction of adult height, pediatric dentists,
orthodontists, and oral/maxillofacial surgeons need to be knowledgeable about a
patient's facial growth patterns to effectively treat them. Some variations in
facial growth have been clinically associated with a poor esthetic self-image,
malocclusion formation and the development of physical and/or functional
deformity. To understand how different genetic factors influence growth and
development patterns, scientists and clinicians study developmental sequences,
malformations and syndromes. While understanding this general information can be
clinically valuable when making treatment decisions for an individual and their
family, the greatest contribution of genetics in clinical practice may be in the
form of personalized or "precision" medicine in the general population. Precision
medicine takes into account knowing a portion or all of a patient's specific DNA
code to estimate how their genetic makeup will influence growth and development
patterns. Ultimately, the identification of key genetic variations at the level
of the individual patient can improve growth predictions for that patient and may
be indicative of how well they will respond to specific forms of treatment.
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