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10.1016/B978-0-12-381328-2.00014-6 http://scihub22266oqcxt.onion/10.1016/B978-0-12-381328-2.00014-6 C4458347!4458347 !21907094     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21907094 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21907094 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+Rev+Neurobiol 2011 ; 98 (ä): 325-72 Nephropedia Template TP {{tp|p=21907094 |t=2011. Genetics and neuropathology of Huntington s disease |pdf=|usr=}}{{21907094 }} gab.com Text Genetics and neuropathology of Huntington s disease JO: Int Rev Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=21907094 #FOAvip Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral and motor decline. The basis of HD is a CAG repeat expansion to >35 CAG in a gene that codes for a ubiquitous protein known as huntingtin, resulting in an expanded N-terminal polyglutamine tract. The size of the expansion is correlated with disease severity, with increasing CAG accelerating the age of onset. A variety of possibilities have been proposed as to the mechanism by which the mutation causes preferential injury to the basal ganglia. The present chapter provides a basic overview of the genetics and pathology of HD. Twit Text FOAVip Genetics and neuropathology of Huntington s disease ????Int Rev Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=21907094 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21907094 #FOAvip English Wikipedia <ref>{{Cite pmid|21907094 }}</ref> Genetics and neuropathology of Huntington s disease #MMPMID21907094 Reiner A ; Dragatsis I ; Dietrich P Int Rev Neurobiol 2011[]; 98 (ä): 325-72 PMID21907094 show ga Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral and motor decline. The basis of HD is a CAG repeat expansion to >35 CAG in a gene that codes for a ubiquitous protein known as huntingtin, resulting in an expanded N-terminal polyglutamine tract. The size of the expansion is correlated with disease severity, with increasing CAG accelerating the age of onset. A variety of possibilities have been proposed as to the mechanism by which the mutation causes preferential injury to the basal ganglia. The present chapter provides a basic overview of the genetics and pathology of HD. |*Genetic Predisposition to Disease [MESH] |Brain/*pathology [MESH] |Humans [MESH] |Huntingtin Protein [MESH] |Huntington Disease/*genetics/*pathology [MESH] |Nerve Tissue Proteins/*genetics [MESH] |Nuclear Proteins/*genetics [MESH]Genetics and neuropathology of Huntington s disease (epmc).pdf DeepDyve Pubget Overpricing