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10.1016/B978-0-12-407698-3.00006-5 http://scihub22266oqcxt.onion/10.1016/B978-0-12-407698-3.00006-5 C4074542!4074542 !23809924     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23809924 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23809924 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Virus+Res 2013 ; 87 (ä): 183-240 Nephropedia Template TP {{tp|p=23809924 |t=2013. Genetic variation and HIV-associated neurologic disease |pdf=|usr=}}{{23809924 }} gab.com Text Genetic variation and HIV-associated neurologic disease JO: Adv Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=23809924 #FOAvip HIV-associated neurologic disease continues to be a significant complication in the era of highly active antiretroviral therapy. A substantial subset of the HIV-infected population shows impaired neuropsychological performance as a result of HIV-mediated neuroinflammation and eventual central nervous system (CNS) injury. CNS compartmentalization of HIV, coupled with the evolution of genetically isolated populations in the CNS, is responsible for poor prognosis in patients with AIDS, warranting further investigation and possible additions to the current therapeutic strategy. This chapter reviews key advances in the field of neuropathogenesis and studies that have highlighted how molecular diversity within the HIV genome may impact HIV-associated neurologic disease. We also discuss the possible functional implications of genetic variation within the viral promoter and possibly other regions of the viral genome, especially in the cells of monocyte-macrophage lineage, which are arguably key cellular players in HIV-associated CNS disease. Twit Text FOAVip Genetic variation and HIV-associated neurologic disease ????Adv Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=23809924 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23809924 #FOAvip English Wikipedia <ref>{{Cite pmid|23809924 }}</ref> Genetic variation and HIV-associated neurologic disease #MMPMID23809924 Dahiya S ; Irish BP ; Nonnemacher MR ; Wigdahl B Adv Virus Res 2013[]; 87 (ä): 183-240 PMID23809924 show ga HIV-associated neurologic disease continues to be a significant complication in the era of highly active antiretroviral therapy. A substantial subset of the HIV-infected population shows impaired neuropsychological performance as a result of HIV-mediated neuroinflammation and eventual central nervous system (CNS) injury. CNS compartmentalization of HIV, coupled with the evolution of genetically isolated populations in the CNS, is responsible for poor prognosis in patients with AIDS, warranting further investigation and possible additions to the current therapeutic strategy. This chapter reviews key advances in the field of neuropathogenesis and studies that have highlighted how molecular diversity within the HIV genome may impact HIV-associated neurologic disease. We also discuss the possible functional implications of genetic variation within the viral promoter and possibly other regions of the viral genome, especially in the cells of monocyte-macrophage lineage, which are arguably key cellular players in HIV-associated CNS disease. |AIDS Dementia Complex/diagnosis/immunology/pathology/*virology [MESH] |Antiretroviral Therapy, Highly Active [MESH] |Central Nervous System Diseases/diagnosis/*immunology/*virology [MESH] |Genetic Variation [MESH] |HIV Infections/drug therapy/pathology/*virology [MESH] |HIV Long Terminal Repeat/genetics [MESH] |HIV-1/genetics/*pathogenicity [MESH] |Humans [MESH] |Macrophages/immunology [MESH] |Monocytes/immunology [MESH] |Promoter Regions, Genetic [MESH] |env Gene Products, Human Immunodeficiency Virus/genetics [MESH] |tat Gene Products, Human Immunodeficiency Virus/genetics [MESH]Genetic variation and HIV-associated neurologic disease (epmc).pdf DeepDyve Pubget Overpricing