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Genetic variants of mucins: unexplored conundrum #MMPMID27838635
Carcinogenesis 2017[Jul]; 38 (7): 671-9 PMID27838635show ga
Mucins are multi-domain high-molecular-weight glycoproteins encoded by large multi-exon genes that are aberrantly overexpressed in inflammation and cancer. Alternative splicing, high mutational rates, and polymorphisms in mucin genes in cancer and inflammation can potentially generate a large repertoire of functionally diverse, disease-specific mucin gene products that can serve as potential biomarkers and therapeutic targets. This review summarizes the current understanding of the genetic variants of mucins in cancer and inflammation, identifies the gaps in our knowledge and discusses the future course of research to discern their functional role and exploit their diagnostic and therapeutic potential.