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2017 ; 130
(4
): 424-432
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Genetic predisposition to hematologic malignancies: management and surveillance
#MMPMID28600339
Godley LA
; Shimamura A
Blood
2017[Jul]; 130
(4
): 424-432
PMID28600339
show ga
As individuals with germ line predisposition to hematologic malignancies are
diagnosed with increasing frequency, the need for clinical surveillance has
become apparent. Unfortunately, few prospective data are available, so
recommendations are based on collective experience and expert consensus. There is
general agreement to advocate for expert consultation or referral of patients to
centers with expertise in these syndromes, since presentations and disease
progression can be subtle, and treatment strategies must be tailored. Here, we
summarize and integrate expert consensus recommendations and medical management
considerations for the patient newly diagnosed with a leukemia predisposition
disorder. Indications to consider additional studies and referral for allogeneic
stem cell transplantation are also discussed.