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2014 ; 4
(11
): a013839
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Genetic networks governing heart development
#MMPMID25280899
Waardenberg AJ
; Ramialison M
; Bouveret R
; Harvey RP
Cold Spring Harb Perspect Med
2014[Oct]; 4
(11
): a013839
PMID25280899
show ga
Animal genomes contain a code for construction of the body plan from a fertilized
egg. Understanding how genome information is deciphered to create the complex
multilayered regulatory systems that drive organismal development, and which
become altered in disease, is one of the greatest challenges in the biological
sciences. The development of methods that effectively represent and communicate
the complexity inherent in gene regulatory networks remains a major barrier. This
review introduces the philosophy of systems biology and discusses recent progress
in understanding the development of the heart at a systems biology level.
|Animals
[MESH]
|Drosophila/embryology/genetics/growth & development
[MESH]
free
free
free
