Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25349169
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Mol+Psychiatry
2015 ; 20
(6
): 786-92
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Genetic background of extreme violent behavior
#MMPMID25349169
Tiihonen J
; Rautiainen MR
; Ollila HM
; Repo-Tiihonen E
; Virkkunen M
; Palotie A
; Pietiläinen O
; Kristiansson K
; Joukamaa M
; Lauerma H
; Saarela J
; Tyni S
; Vartiainen H
; Paananen J
; Goldman D
; Paunio T
Mol Psychiatry
2015[Jun]; 20
(6
): 786-92
PMID25349169
show ga
In developed countries, the majority of all violent crime is committed by a small
group of antisocial recidivistic offenders, but no genes have been shown to
contribute to recidivistic violent offending or severe violent behavior, such as
homicide. Our results, from two independent cohorts of Finnish prisoners,
revealed that a monoamine oxidase A (MAOA) low-activity genotype (contributing to
low dopamine turnover rate) as well as the CDH13 gene (coding for neuronal
membrane adhesion protein) are associated with extremely violent behavior (at
least 10 committed homicides, attempted homicides or batteries). No substantial
signal was observed for either MAOA or CDH13 among non-violent offenders,
indicating that findings were specific for violent offending, and not largely
attributable to substance abuse or antisocial personality disorder. These results
indicate both low monoamine metabolism and neuronal membrane dysfunction as
plausible factors in the etiology of extreme criminal violent behavior, and imply
that at least about 5-10% of all severe violent crime in Finland is attributable
to the aforementioned MAOA and CDH13 genotypes.
free
free
free
