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10.1101/cshperspect.a021139

http://scihub22266oqcxt.onion/10.1101/cshperspect.a021139
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suck abstract from ncbi


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pmid25680982
      Cold+Spring+Harb+Perspect+Med 2015 ; 5 (7 ): a021139
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  • Genetic Approaches to Facilitate Antibacterial Drug Development #MMPMID25680982
  • Schnappinger D
  • Cold Spring Harb Perspect Med 2015[Feb]; 5 (7 ): a021139 PMID25680982 show ga
  • Very few chemically novel agents have been approved for antibacterial chemotherapies during the last 50 yr. Yet new antibacterial drugs are needed to reduce the impact on global health of an increasing number of drug-resistant infections, including highly drug-resistant forms of tuberculosis. This review discusses how genetic approaches can be used to study the mechanism of action of whole-cell screening hits and facilitate target-driven strategies for antimicrobial drug development.
  • |*Drug Design [MESH]
  • |Antitubercular Agents/*therapeutic use [MESH]
  • |Humans [MESH]
  • |Mycobacterium tuberculosis/*genetics [MESH]


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