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2009 ; 61
(10
): 822-35
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Gene therapy of benign gynecological diseases
#MMPMID19446586
Hassan MH
; Othman EE
; Hornung D
; Al-Hendy A
Adv Drug Deliv Rev
2009[Aug]; 61
(10
): 822-35
PMID19446586
show ga
Gene therapy is the introduction of genetic material into patient's cells to
achieve therapeutic benefit. Advances in molecular biology techniques and better
understanding of disease pathogenesis have validated the use of a variety of
genes as potential molecular targets for gene therapy based approaches. Gene
therapy strategies include: mutation compensation of dysregulated genes;
replacement of defective tumor-suppressor genes; inactivation of oncogenes;
introduction of suicide genes; immunogenic therapy and antiangiogenesis based
approaches. Preclinical studies of gene therapy for various gynecological
disorders have not only shown to be feasible, but also showed promising results
in diseases such as uterine leiomyomas and endometriosis. In recent years,
significant improvement in gene transfer technology has led to the development of
targetable vectors, which have fewer side-effects without compromising their
efficacy. This review provides an update on developing gene therapy approaches to
treat common gynecological diseases such as uterine leiomyoma and endometriosis.
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