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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Pathol
2016 ; 69
(6
): 484-9
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Gene of the month: SMARCB1
#MMPMID26941181
Kalimuthu SN
; Chetty R
J Clin Pathol
2016[Jun]; 69
(6
): 484-9
PMID26941181
show ga
SMARCB1 is the core subunit of the SWI/sucrose non-fermenting ATP-dependent
chromatin remodelling complex located on the long arm of chromosome 22 (22q11.2).
Since discovering genetic alterations of the SMARCB1 gene in malignant rhabdoid
tumours, the family of tumours harbouring loss of SMARCB1 expression has been
steadily expanding. In this review, we give a general overview of SMARCB1, its
role in various cancers including germline mutations, association with genetic
syndromes and role in future targeted therapies.