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10.1038/s41598-017-11331-9 http://scihub22266oqcxt.onion/10.1038/s41598-017-11331-9 C5595962!5595962 !28900139     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28900139 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 11427 Nephropedia Template TP {{tp|p=28900139 |t=2017. Gene expression profiling of calcifications in breast cancer |pdf=|usr=}}{{28900139 }} gab.com Text Gene expression profiling of calcifications in breast cancer JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28900139 #FOAvip We investigated the gene expression profiles of calcifications in breast cancer. Gene expression analysis of surgical specimen was performed using Affymetrix GeneChip® Human Gene 2.0 ST arrays in 168 breast cancer patients. The mammographic calcifications were reviewed by three radiologists and classified into three groups according to malignancy probability: breast cancers without suspicious calcifications; breast cancers with low-to-intermediate suspicious calcifications; and breast cancers with highly suspicious calcifications. To identify differentially expressed genes (DEGs) between these three groups, a one-way analysis of variance was performed with post hoc comparisons with Tukey's honest significant difference test. To explore the biological significance of DEGs, we used DAVID for gene ontology analysis and BioLattice for clustering analysis. A total of 2551 genes showed differential expression among the three groups. ERBB2 genes are up-regulated in breast cancers with highly suspicious calcifications (fold change 2.474, p?<?0.001). Gene ontology analysis revealed that the immune, defense and inflammatory responses were decreased in breast cancers with highly suspicious calcifications compared to breast cancers without suspicious calcifications (p from 10(-23) to 10(-8)). The clustering analysis also demonstrated that the immune system is associated with mammographic calcifications (p?<?0.001). Our study showed calcifications in breast cancers are associated with high levels of mRNA expression of ERBB2 and decreased immune system activity. Twit Text FOAVip Gene expression profiling of calcifications in breast cancer ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28900139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28900139 #FOAvip English Wikipedia <ref>{{Cite pmid|28900139 }}</ref> Gene expression profiling of calcifications in breast cancer #MMPMID28900139 Shin SU ; Lee J ; Kim JH ; Kim WH ; Song SE ; Chu A ; Kim HS ; Han W ; Ryu HS ; Moon WK Sci Rep 2017[Sep]; 7 (1 ): 11427 PMID28900139 show ga We investigated the gene expression profiles of calcifications in breast cancer. Gene expression analysis of surgical specimen was performed using Affymetrix GeneChip® Human Gene 2.0 ST arrays in 168 breast cancer patients. The mammographic calcifications were reviewed by three radiologists and classified into three groups according to malignancy probability: breast cancers without suspicious calcifications; breast cancers with low-to-intermediate suspicious calcifications; and breast cancers with highly suspicious calcifications. To identify differentially expressed genes (DEGs) between these three groups, a one-way analysis of variance was performed with post hoc comparisons with Tukey's honest significant difference test. To explore the biological significance of DEGs, we used DAVID for gene ontology analysis and BioLattice for clustering analysis. A total of 2551 genes showed differential expression among the three groups. ERBB2 genes are up-regulated in breast cancers with highly suspicious calcifications (fold change 2.474, p? |*Gene Expression Profiling [MESH] |*Transcriptome [MESH] |Adult [MESH] |Aged [MESH] |Breast Neoplasms/diagnostic imaging/*genetics/*pathology [MESH] |Calcinosis/*genetics [MESH] |Computational Biology/methods [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Image Processing, Computer-Assisted [MESH] |Lymphocytes, Tumor-Infiltrating [MESH] |Mammography [MESH] |Middle Aged [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Staging [MESH]Gene expression profiling of calcifications in breast cancer (epmc).pdf DeepDyve Pubget Overpricing