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10.1038/s41467-018-05281-7 http://scihub22266oqcxt.onion/10.1038/s41467-018-05281-7 C6048131!6048131 !30013096     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30013096 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30013096 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2018 ; 9 (1 ): 2750 Nephropedia Template TP {{tp|p=30013096 |t=2018. Gene expression drives the evolution of dominance |pdf=|usr=}}{{30013096 }} gab.com Text Gene expression drives the evolution of dominance JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30013096 #FOAvip Dominance is a fundamental concept in molecular genetics and has implications for understanding patterns of genetic variation, evolution, and complex traits. However, despite its importance, the degree of dominance in natural populations is poorly quantified. Here, we leverage multiple mating systems in natural populations of Arabidopsis to co-estimate the distribution of fitness effects and dominance coefficients of new amino acid changing mutations. We find that more deleterious mutations are more likely to be recessive than less deleterious mutations. Further, this pattern holds across gene categories, but varies with the connectivity and expression patterns of genes. Our work argues that dominance arises as a consequence of the functional importance of genes and their optimal expression levels. Twit Text FOAVip Gene expression drives the evolution of dominance ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30013096 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30013096 #FOAvip English Wikipedia <ref>{{Cite pmid|30013096 }}</ref> Gene expression drives the evolution of dominance #MMPMID30013096 Huber CD ; Durvasula A ; Hancock AM ; Lohmueller KE Nat Commun 2018[Jul]; 9 (1 ): 2750 PMID30013096 show ga Dominance is a fundamental concept in molecular genetics and has implications for understanding patterns of genetic variation, evolution, and complex traits. However, despite its importance, the degree of dominance in natural populations is poorly quantified. Here, we leverage multiple mating systems in natural populations of Arabidopsis to co-estimate the distribution of fitness effects and dominance coefficients of new amino acid changing mutations. We find that more deleterious mutations are more likely to be recessive than less deleterious mutations. Further, this pattern holds across gene categories, but varies with the connectivity and expression patterns of genes. Our work argues that dominance arises as a consequence of the functional importance of genes and their optimal expression levels. |*Evolution, Molecular [MESH] |*Genes, Dominant [MESH] |*Genes, Plant [MESH] |*Models, Genetic [MESH] |Arabidopsis/*genetics/metabolism [MESH] |Gene Expression [MESH] |Genes, Recessive [MESH] |Genetic Fitness [MESH] |Genetic Variation [MESH] |Genetics, Population [MESH] |Mutation [MESH]Gene expression drives the evolution of dominance (epmc).pdf DeepDyve Pubget Overpricing