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2016 ; 26
(18
): R859-R864
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Gene Flow and Molecular Innovation in Bacteria
#MMPMID27676308
Ruzzini AC
; Clardy J
Curr Biol
2016[Sep]; 26
(18
): R859-R864
PMID27676308
show ga
The small molecules produced by environmental bacteria have been mainstays of
both chemical and biological research for decades, and some have led to important
therapeutic interventions. These small molecules have been shaped by natural
selection as they evolved to fulfill changing functional roles in their native
environments. This minireview describes some recent systematic studies providing
illustrative examples that involve the acquisition and alteration of genetic
information for molecular innovation by bacteria in well-defined environments.
Two different bacterial genera are featured, Pseudonocardia and Salinispora, and,
although the small-molecule repertoires of both have benefited from horizontal
gene transfer, Pseudonocardia spp. have relied on plasmid-based tactics while
Salinispora spp. have relied on chromosomally integrated genomic islands.