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2015 ; 4
(ä): 70-3
Nephropedia Template TP
Uribe-San-Martin R
; Ciampi E
; Lawson-Peralta B
; Acevedo-Gallinato K
; Torrealba-Marchant G
; Campos-Puebla M
; Godoy-Fernández J
Epilepsy Behav Case Rep
2015[]; 4
(ä): 70-3
PMID27195219
show ga
Gelastic epilepsy or laughing seizures have been historically related to children
with hypothalamic hamartomas. We report three adult patients who had gelastic
epilepsy, defined as the presence of seizures with a prominent laugh component,
including brain imaging, surface/invasive electroencephalography, positron
emission tomography, and medical/surgical outcomes. None of the patients had
hamartoma or other hypothalamic lesion. Two patients were classified as having
refractory epilepsy (one had biopsy-proven neurocysticercosis and the other one
hippocampal sclerosis and temporal cortical dysplasia). The third patient had no
lesion on MRI and had complete control with carbamazepine. Both lesional patients
underwent resective surgery, one with complete seizure control and the other one
with poor outcome. Although hypothalamic hamartomas should always be ruled out in
patients with gelastic epilepsy, laughing seizures can also arise from frontal
and temporal lobe foci, which can be surgically removed. In addition, we present
the first case of gelastic epilepsy due to neurocysticercosis.