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2017 ; 11
(5
): 579-589
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Gastroparesis Updates on Pathogenesis and Management
#MMPMID28535580
Liu N
; Abell T
Gut Liver
2017[Sep]; 11
(5
): 579-589
PMID28535580
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Gastroparesis (Gp) is a chronic disease that presents with clinical symptoms of
early satiety, bloating, nausea, vomiting, and abdominal pain. Along with these
symptoms, an objective finding of delayed gastric emptying, along with a
documented absence of gastric outlet obstruction, are required for diagnosis.
This article focuses on updates in the pathogenesis and management of Gp. Recent
studies on full thickness biopsies of Gp patients have shed light on the complex
interactions of the central, autonomic, and enteric nervous systems, which all
play key roles in maintaining normal gut motility. The management of Gp has
evolved beyond prokinetics and antiemetics with the use of gastric electrical
stimulators (GES). In addition, this review aims to introduce the concept of
gastroparesis-like syndrome (GLS). GLS helps groups of patients who have the
cardinal symptoms of Gp but have a normal or rapid emptying test. Recent tests
have shown that patients with Gp and GLS have similar pathophysiology, benefit
greatly from GES placement, and likely should be treated in a similar manner.
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