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2014 ; 30
(6
): 583-8
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Gastroduodenal mucosal defense
#MMPMID25229259
Kemmerly T
; Kaunitz JD
Curr Opin Gastroenterol
2014[Nov]; 30
(6
): 583-8
PMID25229259
show ga
PURPOSE OF REVIEW: To review recent developments in the field of gastroduodenal
mucosal defense. RECENT FINDINGS: Research in the field of gastroduodenal mucosal
defense has focused on continued elucidation of molecular mechanisms that protect
the mucosa and influence healing at the cellular level. Review of literature over
the past year reveals that familiar proteins and mediators, such as nitric oxide,
toll-like receptors, nucleotide-binding oligomerization domain-containing
proteins (NOD2), ?-defensins, macrophages, dendritic cells, mucins, autophagy,
and the influence of aging and diet, are still subjects of study, but also brings
into light new processes and mediators, such as dual oxidases, defense against
radiation injuries, and novel proteins such as ZBP-89. SUMMARY: These new
published findings contribute to our overall understanding of gastroduodenal
defense and suggest innovative avenues of future research and possible novel
therapeutic targets.