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2014 ; 3
(1
): 56-62
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Garland-pattern postinfectious glomerulonephritis with IgA-dominant deposition
#MMPMID28509246
Kanno M
; Tanaka K
; Kimura H
; Watanabe K
; Hayashi Y
; Asahi K
; Nakayama M
; Joh K
; Watanabe T
CEN Case Rep
2014[May]; 3
(1
): 56-62
PMID28509246
show ga
A histological subtype of acute postinfectious glomerulonephritis (APIGN), the
garland pattern, is identified not only by characteristic histological findings,
but also by severe clinical course as compared with typical APIGN. However, since
the morbidity of APIGN has decreased globally, there have been few reports on
this disease form in developed countries during the last two decades. Herein, we
report a case of adolescent garland-pattern APIGN with IgA-dominant deposits,
presenting with severe nephrotic syndrome and protracted hematuria and
proteinuria. We also review the clinical and histological features of 13
previously reported cases in Japan and compare them with our present case. In our
review, we confirmed IgA deposition in at least three of these patients, in whom
urinary protein excretion tended to be greater than those patients without IgA.
Greater awareness of this condition is necessary to ensure appropriate follow-up
of the clinical course of patients with garland-pattern APIGN with IgA
deposition.