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2017 ; 11
(ä): 246
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Ganaxolone: A New Treatment for Neonatal Seizures
#MMPMID28878622
Yawno T
; Miller SL
; Bennet L
; Wong F
; Hirst JJ
; Fahey M
; Walker DW
Front Cell Neurosci
2017[]; 11
(ä): 246
PMID28878622
show ga
Neonatal seizures are amongst the most common neurologic conditions managed by a
neonatal care service. Seizures can exacerbate existing brain injury, induce "de
novo" injury, and are associated with neurodevelopmental disabilities in
post-neonatal life. In this mini-review, we present evidence in support of the
use of ganaxolone, a GABA(A) agonist neurosteroid, as a novel neonatal therapy.
We discuss evidence that ganaxolone can provide both seizure control and
neuroprotection with a high safety profile when administered early following
birth-related hypoxia, and show evidence that it is likely to prevent or reduce
the incidence of the enduring disabilities associated with preterm birth,
cerebral palsy, and epilepsy. We suggest that ganaxolone is an ideal anti-seizure
treatment because it can be safely used prospectively, with minimal or no adverse
effects on the neonatal brain.
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