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10.3390/ijms19030905

http://scihub22266oqcxt.onion/10.3390/ijms19030905
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suck abstract from ncbi

pmid29562695
      Int+J+Mol+Sci 2018 ; 19 (3 ): ?
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  • Galectins as Molecular Targets for Therapeutic Intervention #MMPMID29562695
  • Dings RPM ; Miller MC ; Griffin RJ ; Mayo KH
  • Int J Mol Sci 2018[Mar]; 19 (3 ): ? PMID29562695 show ga
  • Galectins are a family of small, highly conserved, molecular effectors that mediate various biological processes, including chemotaxis and angiogenesis, and that function by interacting with various cell surface glycoconjugates, usually targeting ?-galactoside epitopes. Because of their significant involvement in various biological functions and pathologies, galectins have become a focus of therapeutic discovery for clinical intervention against cancer, among other pathological disorders. In this review, we focus on understanding galectin structure-function relationships, their mechanisms of action on the molecular level, and targeting them for therapeutic intervention against cancer.
  • |*Molecular Targeted Therapy [MESH]
  • |Animals [MESH]
  • |Carbohydrates/chemistry [MESH]
  • |Drug Therapy, Combination [MESH]
  • |Galectins/chemistry/*metabolism [MESH]


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