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10.1093/glycob/cwu062

http://scihub22266oqcxt.onion/10.1093/glycob/cwu062
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C4153759!4153759!24973253
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suck abstract from ncbi


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pmid24973253      Glycobiology 2014 ; 24 (10): 921-5
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  • Galectin-1 links tumor hypoxia and radiotherapy #MMPMID24973253
  • Kuo P; Le QT
  • Glycobiology 2014[Oct]; 24 (10): 921-5 PMID24973253show ga
  • Radiation therapy is a main stay in treating solid tumors and plays a significant role in definitive and adjuvant therapy. Unfortunately, local control remains a challenge, in which the success of radiotherapy is largely dictated by tumor hypoxia, DNA damage repair and the antitumor immune response. Extensive efforts have therefore been devoted to targeting the factors that attenuate tumor radiosensitivity, although with limited success. Mounting evidence suggests that tumor and endothelial cells may utilize galectin-1 (Gal-1) for protection against radiation through several mechanisms. Targeting Gal-1 in combination with radiotherapy provides an exciting approach to address several radiation-prohibitive mechanisms.
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