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2014 ; 24
(10
): 921-5
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Galectin-1 links tumor hypoxia and radiotherapy
#MMPMID24973253
Kuo P
; Le QT
Glycobiology
2014[Oct]; 24
(10
): 921-5
PMID24973253
show ga
Radiation therapy is a main stay in treating solid tumors and plays a significant
role in definitive and adjuvant therapy. Unfortunately, local control remains a
challenge, in which the success of radiotherapy is largely dictated by tumor
hypoxia, DNA damage repair and the antitumor immune response. Extensive efforts
have therefore been devoted to targeting the factors that attenuate tumor
radiosensitivity, although with limited success. Mounting evidence suggests that
tumor and endothelial cells may utilize galectin-1 (Gal-1) for protection against
radiation through several mechanisms. Targeting Gal-1 in combination with
radiotherapy provides an exciting approach to address several
radiation-prohibitive mechanisms.