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10.1038/nbt.3968 http://scihub22266oqcxt.onion/10.1038/nbt.3968 C5953555!5953555 !28922346     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28922346 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Biotechnol 2017 ; 35 (10 ): 940-950 Nephropedia Template TP {{tp|p=28922346 |t=2017. GRID-seq reveals the global RNA-chromatin interactome |pdf=|usr=}}{{28922346 }} gab.com Text GRID-seq reveals the global RNA-chromatin interactome JO: Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=28922346 #FOAvip Higher eukaryotic genomes are bound by a large number of coding and non-coding RNAs, but approaches to comprehensively map the identity and binding sites of these RNAs are lacking. Here we report a method to capture in situ global RNA interactions with DNA by deep sequencing (GRID-seq), which enables the comprehensive identification of the entire repertoire of chromatin-interacting RNAs and their respective binding sites. In human, mouse, and Drosophila cells, we detected a large set of tissue-specific coding and non-coding RNAs that are bound to active promoters and enhancers, especially super-enhancers. Assuming that most mRNA-chromatin interactions indicate the physical proximity of a promoter and an enhancer, we constructed a three-dimensional global connectivity map of promoters and enhancers, revealing transcription-activity-linked genomic interactions in the nucleus. Twit Text FOAVip GRID-seq reveals the global RNA-chromatin interactome ????Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=28922346 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28922346 #FOAvip English Wikipedia <ref>{{Cite pmid|28922346 }}</ref> GRID-seq reveals the global RNA-chromatin interactome #MMPMID28922346 Li X ; Zhou B ; Chen L ; Gou LT ; Li H ; Fu XD Nat Biotechnol 2017[Oct]; 35 (10 ): 940-950 PMID28922346 show ga Higher eukaryotic genomes are bound by a large number of coding and non-coding RNAs, but approaches to comprehensively map the identity and binding sites of these RNAs are lacking. Here we report a method to capture in situ global RNA interactions with DNA by deep sequencing (GRID-seq), which enables the comprehensive identification of the entire repertoire of chromatin-interacting RNAs and their respective binding sites. In human, mouse, and Drosophila cells, we detected a large set of tissue-specific coding and non-coding RNAs that are bound to active promoters and enhancers, especially super-enhancers. Assuming that most mRNA-chromatin interactions indicate the physical proximity of a promoter and an enhancer, we constructed a three-dimensional global connectivity map of promoters and enhancers, revealing transcription-activity-linked genomic interactions in the nucleus. |Animals [MESH] |Cell Line, Tumor [MESH] |Chromatin/*metabolism [MESH] |DNA/*isolation & purification [MESH] |Drosophila [MESH] |Enhancer Elements, Genetic [MESH] |High-Throughput Nucleotide Sequencing/*methods [MESH] |Humans [MESH] |Promoter Regions, Genetic [MESH] |RNA/*metabolism [MESH]GRID-seq reveals the global RNA-chromatin interactome (epmc).pdf DeepDyve Pubget Overpricing