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2016 ; 3
(ä): 63-67
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GPC-3 in hepatocellular carcinoma: current perspectives
#MMPMID27878117
Wu Y
; Liu H
; Ding H
J Hepatocell Carcinoma
2016[]; 3
(ä): 63-67
PMID27878117
show ga
Glypican-3 (GPC3), a member of heparan sulfate proteoglycans, attaches to the
cell membrane and is frequently observed to be elevated in hepatocellular
carcinoma (HCC). However, GPC3 is not detected in normal liver tissues and benign
liver lesions. Consequently, GPC3 is currently being used as a diagnostic
biomarker and HCC-specific positron emission computed tomography probe to
identify HCCs in normal liver tissues and benign liver lesions. The
overexpression of GPC-3 in serum or liver tissue also predicts poor prognosis for
HCC patients. In addition, GPC3 promotes HCC growth and metastasis by activating
the canonical Wnt and other signaling pathways. Targeting of GPC3, including
GC33, HN3 and YP7, might offer new immunotherapeutic tools for HCC treatment.