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2015 ; 16
(ä): 346
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GOTA: GO term annotation of biomedical literature
#MMPMID26511083
Di Lena P
; Domeniconi G
; Margara L
; Moro G
BMC Bioinformatics
2015[Oct]; 16
(ä): 346
PMID26511083
show ga
BACKGROUND: Functional annotation of genes and gene products is a major challenge
in the post-genomic era. Nowadays, gene function curation is largely based on
manual assignment of Gene Ontology (GO) annotations to genes by using published
literature. The annotation task is extremely time-consuming, therefore there is
an increasing interest in automated tools that can assist human experts. RESULTS:
Here we introduce GOTA, a GO term annotator for biomedical literature. The
proposed approach makes use only of information that is readily available from
public repositories and it is easily expandable to handle novel sources of
information. We assess the classification capabilities of GOTA on a large
benchmark set of publications. The overall performances are encouraging in
comparison to the state of the art in multi-label classification over large
taxonomies. Furthermore, the experimental tests provide some interesting insights
into the potential improvement of automated annotation tools. CONCLUSIONS: GOTA
implements a flexible and expandable model for GO annotation of biomedical
literature. The current version of the GOTA tool is freely available at
http://gota.apice.unibo.it.