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2015 ; 167
(1-3
): 4-11
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GABAergic mechanisms of hippocampal hyperactivity in schizophrenia
#MMPMID25449711
Heckers S
; Konradi C
Schizophr Res
2015[Sep]; 167
(1-3
): 4-11
PMID25449711
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Schizophrenia is associated with abnormalities of hippocampal structure and
function. Neuroimaging studies have shown that the hippocampus is hyperactive in
schizophrenia. Here we explore GABAergic mechanisms of this hippocampal
hyperactivity. The initial evidence for GABAergic abnormalities of the
hippocampus in schizophrenia came from post-mortem studies of interneuron number,
protein expression, and gene expression. These studies revealed marked decreases
in gene and protein expression of somatostatin-positive and parvalbumin-positive
interneurons, and indicated reduced interneuron numbers. Animal studies of
decreased parvalbumin and NMDA-receptor function have shown that selective
abnormalities of hippocampal interneurons mimic some of the cognitive deficits
and clinical features of schizophrenia. The post-mortem and animal studies are
consistent with the neuroimaging finding of increased hippocampal activity in
schizophrenia, which can explain some of the psychotic symptoms and cognitive
deficits. Taken together, these findings may guide the development of biomarkers
and the development of new treatments for psychosis.
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