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2015 ; 2015
(ä): bav059
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G4RNA: an RNA G-quadruplex database
#MMPMID26200754
Garant JM
; Luce MJ
; Scott MS
; Perreault JP
Database (Oxford)
2015[Jun]; 2015
(ä): bav059
PMID26200754
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G-quadruplexes (G4) are tetrahelical structures formed from planar arrangement of
guanines in nucleic acids. A simple, regular motif was originally proposed to
describe G4-forming sequences. More recently, however, formation of G4 was
discovered to depend, at least in part, on the contextual backdrop of neighboring
sequences. Prediction of G4 folding is thus becoming more challenging as G4
outlier structures, not described by the originally proposed motif, are
increasingly reported. Recent observations thus call for a comprehensive tool,
capable of consolidating the expanding information on tested G4s, in order to
conduct systematic comparative analyses of G4-promoting sequences. The G4RNA
Database we propose was designed to help meet the need for easily-retrievable
data on known RNA G4s. A user-friendly, flexible query system allows for data
retrieval on experimentally tested sequences, from many separate genes, to assess
G4-folding potential. Query output sorts data according to sequence position, G4
likelihood, experimental outcomes and associated bibliographical references.
G4RNA also provides an ideal foundation to collect and store additional sequence
and experimental data, considering the growing interest G4s currently generate.