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2015 ; 43
(18
): 8627-37
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G-quadruplexes and their regulatory roles in biology
#MMPMID26350216
Rhodes D
; Lipps HJ
Nucleic Acids Res
2015[Oct]; 43
(18
): 8627-37
PMID26350216
show ga
'If G-quadruplexes form so readily in vitro, Nature will have found a way of
using them in vivo' (Statement by Aaron Klug over 30 years ago).During the last
decade, four-stranded helical structures called G-quadruplex (or G4) have emerged
from being a structural curiosity observed in vitro, to being recognized as a
possible nucleic acid based mechanism for regulating multiple biological
processes in vivo. The sequencing of many genomes has revealed that they are rich
in sequence motifs that have the potential to form G-quadruplexes and that their
location is non-random, correlating with functionally important genomic regions.
In this short review, we summarize recent evidence for the in vivo presence and
function of DNA and RNA G-quadruplexes in various cellular pathways including DNA
replication, gene expression and telomere maintenance. We also highlight
remaining open questions that will have to be addressed in the future.
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