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10.1007/978-1-61779-092-8_8 http://scihub22266oqcxt.onion/10.1007/978-1-61779-092-8_8 C4772873!4772873 !21461813     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21461813 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Methods+Mol+Biol 2011 ; 735 (ä): 77-96 Nephropedia Template TP {{tp|p=21461813 |t=2011. G-quadruplex structures and G-quadruplex-interactive compounds |pdf=|usr=}}{{21461813 }} gab.com Text G-quadruplex structures and G-quadruplex-interactive compounds JO: Methods Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=21461813 #FOAvip G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures. G-quadruplex-interactive compounds have been shown to inhibit telomerase access as well as telomere capping. Nuclear magnetic resonance (NMR) spectroscopy has been shown to be a powerful method in determining the G-quadruplex structures under physiologically relevant conditions. We present the NMR methodology used in our research group for structure determination of G-quadruplexes in solution and their interactions with small molecule compounds. An example of a G-quadruplex structure formed in the human telomere sequence recently solved in our laboratory is used as an example. Twit Text FOAVip G-quadruplex structures and G-quadruplex-interactive compounds ????Methods Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=21461813 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21461813 #FOAvip English Wikipedia <ref>{{Cite pmid|21461813 }}</ref> G-quadruplex structures and G-quadruplex-interactive compounds #MMPMID21461813 Mathad RI ; Yang D Methods Mol Biol 2011[]; 735 (ä): 77-96 PMID21461813 show ga G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3' G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures. G-quadruplex-interactive compounds have been shown to inhibit telomerase access as well as telomere capping. Nuclear magnetic resonance (NMR) spectroscopy has been shown to be a powerful method in determining the G-quadruplex structures under physiologically relevant conditions. We present the NMR methodology used in our research group for structure determination of G-quadruplexes in solution and their interactions with small molecule compounds. An example of a G-quadruplex structure formed in the human telomere sequence recently solved in our laboratory is used as an example. |*G-Quadruplexes [MESH] |*Nucleic Acid Conformation [MESH] |Guanine/*chemistry [MESH] |Humans [MESH] |Hydrogen Bonding [MESH] |Magnetic Resonance Spectroscopy [MESH] |Models, Molecular [MESH] |Organometallic Compounds/chemical synthesis/*chemistry/pharmacology [MESH] |Potassium/chemistry [MESH] |Structure-Activity Relationship [MESH] |Telomerase/antagonists & inhibitors/chemistry/metabolism [MESH]G-quadruplex structures and G-quadruplex-interactive compounds (epmc).pdf DeepDyve Pubget Overpricing