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10.1073/pnas.1609996114 http://scihub22266oqcxt.onion/10.1073/pnas.1609996114 C5488913!5488913 !28584129     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28584129 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (25 ): 6498-6503 Nephropedia Template TP {{tp|p=28584129 |t=2017. Future of fundamental discovery in US biomedical research |pdf=|usr=}}{{28584129 }} gab.com Text Future of fundamental discovery in US biomedical research JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28584129 #FOAvip Young researchers are crucially important for basic science as they make unexpected, fundamental discoveries. Since 1982, we find a steady drop in the number of grant-eligible basic-science faculty [principal investigators (PIs)] younger than 46. This fall occurred over a 32-y period when inflation-corrected congressional funds for NIH almost tripled. During this time, the PI success ratio (fraction of basic-science PIs who are R01 grantees) dropped for younger PIs (below 46) and increased for older PIs (above 55). This age-related bias seems to have caused the steady drop in the number of young basic-science PIs and could reduce future US discoveries in fundamental biomedical science. The NIH recognized this bias in its 2008 early-stage investigator (ESI) policy to fund young PIs at higher rates. We show this policy is working and recommend that it be enhanced by using better data. Together with the National Institute of General Medical Sciences (NIGMS) Maximizing Investigators' Research Award (MIRA) program to reward senior PIs with research time in exchange for less funding, this may reverse a decades-long trend of more money going to older PIs. To prepare young scientists for increased demand, additional resources should be devoted to transitional postdoctoral fellowships already offered by NIH. Twit Text FOAVip Future of fundamental discovery in US biomedical research ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28584129 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28584129 #FOAvip English Wikipedia <ref>{{Cite pmid|28584129 }}</ref> Future of fundamental discovery in US biomedical research #MMPMID28584129 Levitt M ; Levitt JM Proc Natl Acad Sci U S A 2017[Jun]; 114 (25 ): 6498-6503 PMID28584129 show ga Young researchers are crucially important for basic science as they make unexpected, fundamental discoveries. Since 1982, we find a steady drop in the number of grant-eligible basic-science faculty [principal investigators (PIs)] younger than 46. This fall occurred over a 32-y period when inflation-corrected congressional funds for NIH almost tripled. During this time, the PI success ratio (fraction of basic-science PIs who are R01 grantees) dropped for younger PIs (below 46) and increased for older PIs (above 55). This age-related bias seems to have caused the steady drop in the number of young basic-science PIs and could reduce future US discoveries in fundamental biomedical science. The NIH recognized this bias in its 2008 early-stage investigator (ESI) policy to fund young PIs at higher rates. We show this policy is working and recommend that it be enhanced by using better data. Together with the National Institute of General Medical Sciences (NIGMS) Maximizing Investigators' Research Award (MIRA) program to reward senior PIs with research time in exchange for less funding, this may reverse a decades-long trend of more money going to older PIs. To prepare young scientists for increased demand, additional resources should be devoted to transitional postdoctoral fellowships already offered by NIH. |Adult [MESH] |Biomedical Research/*economics [MESH] |Faculty [MESH] |Financing, Organized/economics [MESH] |Humans [MESH] |Middle Aged [MESH] |National Institutes of Health (U.S.)/economics [MESH] |Research Personnel/*economics [MESH]Future of fundamental discovery in US biomedical research (epmc).pdf DeepDyve Pubget Overpricing