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10.1016/j.idc.2012.08.003

http://scihub22266oqcxt.onion/10.1016/j.idc.2012.08.003
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C4624290!4624290 !23083826
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suck abstract from ncbi


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pmid23083826
      Infect+Dis+Clin+North+Am 2012 ; 26 (4 ): 949-66
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  • Future classes of hepatitis C virus therapeutic agents #MMPMID23083826
  • Chen JY ; Chung RT
  • Infect Dis Clin North Am 2012[Dec]; 26 (4 ): 949-66 PMID23083826 show ga
  • Recent advances in understanding of the molecular characteristics of the hepatitis C virus have led to the development of novel antiviral therapeutics. Direct-acting antivirals are designed to inhibit viral targets, whereas host-targeted antivirals block host factors that are used by the virus for its own life cycle. The rapid development of agents in multiple classes has led to the promise of shorter therapy duration, an improved side effect profile, and eventually interferon-sparing regimens. This article reviews novel hepatitis C virus therapeutics in development, including mechanism of action, efficacy, and adverse effects.
  • |Antiviral Agents/*therapeutic use [MESH]
  • |Hepacivirus/*isolation & purification/physiology [MESH]
  • |Hepatitis C, Chronic/*drug therapy/virology [MESH]
  • |Host-Pathogen Interactions [MESH]


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