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2012 ; 26
(4
): 949-66
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Future classes of hepatitis C virus therapeutic agents
#MMPMID23083826
Chen JY
; Chung RT
Infect Dis Clin North Am
2012[Dec]; 26
(4
): 949-66
PMID23083826
show ga
Recent advances in understanding of the molecular characteristics of the
hepatitis C virus have led to the development of novel antiviral therapeutics.
Direct-acting antivirals are designed to inhibit viral targets, whereas
host-targeted antivirals block host factors that are used by the virus for its
own life cycle. The rapid development of agents in multiple classes has led to
the promise of shorter therapy duration, an improved side effect profile, and
eventually interferon-sparing regimens. This article reviews novel hepatitis C
virus therapeutics in development, including mechanism of action, efficacy, and
adverse effects.