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2014 ; 2014
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Fungal toenail infections
#MMPMID24625577
Ferrari J
BMJ Clin Evid
2014[Mar]; 2014
(ä): ä PMID24625577
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INTRODUCTION: Fungal infections are reported to cause 23% of foot diseases and
50% of nail conditions in people seen by dermatologists, but are less common in
the general population, affecting 3% to 12% of people. METHODS AND OUTCOMES: We
conducted a systematic review and aimed to answer the following clinical
questions: What are the effects of oral treatments for fungal toenail infections
in adults? What are the effects of topical treatments for fungal toenail
infections in adults? We searched: Medline, Embase, The Cochrane Library, and
other important databases up to October 2013 (Clinical Evidence reviews are
updated periodically; please check our website for the most up-to-date version of
this review). We included harms alerts from relevant organisations such as the US
Food and Drug Administration (FDA) and the UK Medicines and Healthcare products
Regulatory Agency (MHRA). RESULTS: We found 13 studies that met our inclusion
criteria. We performed a GRADE evaluation of the quality of evidence for
interventions. CONCLUSIONS: In this systematic review, we present information
relating to the effectiveness and safety of the following interventions:
amorolfine, butenafine, ciclopirox, fluconazole, itraconazole, terbinafine,
tioconazole, and topical ketoconazole.
|Administration, Oral
[MESH]
|Administration, Topical
[MESH]
|Antifungal Agents/administration & dosage/*therapeutic use
[MESH]