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2014 ; 5
(7
): a019661
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Fungal Pathogens: Survival and Replication within Macrophages
#MMPMID25384769
Gilbert AS
; Wheeler RT
; May RC
Cold Spring Harb Perspect Med
2014[Nov]; 5
(7
): a019661
PMID25384769
show ga
The innate immune system is a critical line of defense against pathogenic fungi.
Macrophages act at an early stage of infection, detecting and phagocytizing
infectious propagules. To avoid killing at this stage, fungal pathogens use
diverse strategies ranging from evasion of uptake to intracellular parasitism.
This article will discuss five of the most important human fungal pathogens
(Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, Coccidiodes
immitis, and Histoplasma capsulatum) and consider the strategies and virulence
factors adopted by each to survive and replicate within macrophages.