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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cell+Mol+Med
2015 ; 19
(9
): 2075-83
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Functions of Shp2 in cancer
#MMPMID26088100
Zhang J
; Zhang F
; Niu R
J Cell Mol Med
2015[Sep]; 19
(9
): 2075-83
PMID26088100
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Diagnostics and therapies have shown evident advances. Tumour surgery,
chemotherapy and radiotherapy are the main techniques in treat cancers. Targeted
therapy and drug resistance are the main focus in cancer research, but many
molecular intracellular mechanisms remain unknown. Src homology region
2-containing protein tyrosine phosphatase 2 (Shp2) is associated with breast
cancer, leukaemia, lung cancer, liver cancer, gastric cancer, laryngeal cancer,
oral cancer and other cancer types. Signalling pathways involving Shp2 have also
been discovered. Shp2 is related to many diseases. Mutations in the ptpn11 gene
cause Noonan syndrome, LEOPARD syndrome and childhood leukaemia. Shp2 is also
involved in several cancer-related processes, including cancer cell invasion and
metastasis, apoptosis, DNA damage, cell proliferation, cell cycle and drug
resistance. Based on the structure and function of Shp2, scientists have
investigated specific mechanisms involved in cancer. Shp2 may be a potential
therapeutic target because this phosphatase is implicated in many aspects.
Furthermore, Shp2 inhibitors have been used in experiments to develop treatment
strategies. However, conflicting results related to Shp2 functions have been
presented in the literature, and such results should be resolved in future
studies.
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