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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Biol+Chem
2016 ; 291
(29
): 14904-12
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Functions of Polyamines in Mammals
#MMPMID27268251
Pegg AE
J Biol Chem
2016[Jul]; 291
(29
): 14904-12
PMID27268251
show ga
The content of spermidine and spermine in mammalian cells has important roles in
protein and nucleic acid synthesis and structure, protection from oxidative
damage, activity of ion channels, cell proliferation, differentiation, and
apoptosis. Spermidine is essential for viability and acts as the precursor of
hypusine, a post-translational addition to eIF5A allowing the translation of
mRNAs encoding proteins containing polyproline tracts. Studies with Gy mice and
human patients with the very rare X-linked genetic condition Snyder-Robinson
syndrome that both lack spermine synthase show clearly that the correct
spermine:spermidine ratio is critical for normal growth and development.