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10.1021/acs.chemrev.6b00296 http://scihub22266oqcxt.onion/10.1021/acs.chemrev.6b00296 C5528147!5528147 !27585283     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27585283 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Chem+Rev 2016 ; 116 (20 ): 12688-12710 Nephropedia Template TP {{tp|p=27585283 |t=2016. Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases |pdf=|usr=}}{{27585283 }} gab.com Text Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases JO: Chem Rev http://www.kidney.de/pget.php?&tw=1&pmid=27585283 #FOAvip The AID/APOBEC family enzymes convert cytosines in single-stranded DNA to uracils, causing base substitutions and strand breaks. They are induced by cytokines produced during the body's inflammatory response to infections, and they help combat infections through diverse mechanisms. AID is essential for the maturation of antibodies and causes mutations and deletions in antibody genes through somatic hypermutation (SHM) and class-switch recombination (CSR) processes. One member of the APOBEC family, APOBEC1, edits mRNA for a protein involved in lipid transport. Members of the APOBEC3 subfamily in humans (APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H) inhibit infections of viruses such as HIV-1, HBV, and HCV, and retrotransposition of endogenous retroelements through mutagenic and nonmutagenic mechanisms. There is emerging consensus that these enzymes can cause mutations in the cellular genome at replication forks or within transcription bubbles depending on the physiological state of the cell and the phase of the cell cycle during which they are expressed. We describe here the state of knowledge about the structures of these enzymes, regulation of their expression, and both the advantageous and deleterious consequences of their expression, including carcinogenesis. We highlight similarities among them and present a holistic view of their regulation and function. Twit Text FOAVip Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases ????Chem Rev http://www.kidney.de/pget.php?&tw=1&pmid=27585283 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27585283 #FOAvip English Wikipedia <ref>{{Cite pmid|27585283 }}</ref> Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases #MMPMID27585283 Siriwardena SU ; Chen K ; Bhagwat AS Chem Rev 2016[Oct]; 116 (20 ): 12688-12710 PMID27585283 show ga The AID/APOBEC family enzymes convert cytosines in single-stranded DNA to uracils, causing base substitutions and strand breaks. They are induced by cytokines produced during the body's inflammatory response to infections, and they help combat infections through diverse mechanisms. AID is essential for the maturation of antibodies and causes mutations and deletions in antibody genes through somatic hypermutation (SHM) and class-switch recombination (CSR) processes. One member of the APOBEC family, APOBEC1, edits mRNA for a protein involved in lipid transport. Members of the APOBEC3 subfamily in humans (APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H) inhibit infections of viruses such as HIV-1, HBV, and HCV, and retrotransposition of endogenous retroelements through mutagenic and nonmutagenic mechanisms. There is emerging consensus that these enzymes can cause mutations in the cellular genome at replication forks or within transcription bubbles depending on the physiological state of the cell and the phase of the cell cycle during which they are expressed. We describe here the state of knowledge about the structures of these enzymes, regulation of their expression, and both the advantageous and deleterious consequences of their expression, including carcinogenesis. We highlight similarities among them and present a holistic view of their regulation and function. |AICDA (Activation-Induced Cytidine Deaminase) [MESH] |APOBEC Deaminases/metabolism [MESH] |Animals [MESH] |Cytidine Deaminase/*metabolism [MESH] |DNA/*metabolism [MESH]Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases (epmc).pdf DeepDyve Pubget Overpricing