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10.1007/s13277-015-4127-2 http://scihub22266oqcxt.onion/10.1007/s13277-015-4127-2 C4689759!4689759 !26411672     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26411672 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26411672 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Tumour+Biol 2015 ; 36 (12 ): 9119-26 Nephropedia Template TP {{tp|p=26411672 |t=2015. Functional significance of macrophages in pancreatic cancer biology |pdf=|usr=}}{{26411672 }} gab.com Text Functional significance of macrophages in pancreatic cancer biology JO: Tumour Biol http://www.kidney.de/pget.php?&tw=1&pmid=26411672 #FOAvip Pancreatic ductal adenocarcinoma (PDA) is a lethal disease that is usually diagnosed at late stage with few effective therapies. Despite the rapid progress on the genomics and proteomics of the neoplastic cells, therapies that targeted the pancreatic cancer cells proved to be inefficient, which promoted the researchers to turn their attentions to the microenvironment. Currently, various studies had proposed the microenvironment to be a contributing factor for PDA and pervasive researches showed that macrophages within the malignancy correlate with the malignant phenotype of the disease and were reported to a new therapeutic target. Generally, the pro-tumoral effects of macrophages can be summarized as angiogenesis promotion, immunosuppression, matrix remodeling and so on. Hence, a comprehensive understanding of the biologic behaviors of macrophages and their critical role in PDA development may provide new directions for the managements of the lethal disease. In this review, we will summarize the recent advancements on macrophages as pivotal players in PDA biology and the current knowledge about anti-macrophages as a novel strategy against cancer, with the expectation that more efficient therapies will be developed in the near future. Twit Text FOAVip Functional significance of macrophages in pancreatic cancer biology ????Tumour Biol http://www.kidney.de/pget.php?&tw=1&pmid=26411672 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26411672 #FOAvip English Wikipedia <ref>{{Cite pmid|26411672 }}</ref> Functional significance of macrophages in pancreatic cancer biology #MMPMID26411672 Hu H ; Jiao F ; Han T ; Wang LW Tumour Biol 2015[Dec]; 36 (12 ): 9119-26 PMID26411672 show ga Pancreatic ductal adenocarcinoma (PDA) is a lethal disease that is usually diagnosed at late stage with few effective therapies. Despite the rapid progress on the genomics and proteomics of the neoplastic cells, therapies that targeted the pancreatic cancer cells proved to be inefficient, which promoted the researchers to turn their attentions to the microenvironment. Currently, various studies had proposed the microenvironment to be a contributing factor for PDA and pervasive researches showed that macrophages within the malignancy correlate with the malignant phenotype of the disease and were reported to a new therapeutic target. Generally, the pro-tumoral effects of macrophages can be summarized as angiogenesis promotion, immunosuppression, matrix remodeling and so on. Hence, a comprehensive understanding of the biologic behaviors of macrophages and their critical role in PDA development may provide new directions for the managements of the lethal disease. In this review, we will summarize the recent advancements on macrophages as pivotal players in PDA biology and the current knowledge about anti-macrophages as a novel strategy against cancer, with the expectation that more efficient therapies will be developed in the near future. |Adenocarcinoma/*genetics/pathology [MESH] |Carcinoma, Pancreatic Ductal/*genetics/pathology [MESH] |Humans [MESH] |Macrophages/metabolism/*pathology [MESH] |Pancreas/metabolism/pathology [MESH] |Stromal Cells/metabolism/pathology [MESH]Functional significance of macrophages in pancreatic cancer biology (epmc).pdf DeepDyve Pubget Overpricing