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2015 ; 60
(10
): R211-37
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Functional optical coherence tomography: principles and progress
#MMPMID25951836
Kim J
; Brown W
; Maher JR
; Levinson H
; Wax A
Phys Med Biol
2015[May]; 60
(10
): R211-37
PMID25951836
show ga
In the past decade, several functional extensions of optical coherence tomography
(OCT) have emerged, and this review highlights key advances in instrumentation,
theoretical analysis, signal processing and clinical application of these
extensions. We review five principal extensions: Doppler OCT (DOCT),
polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE),
spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been
further developed with studies in both ex vivo and in vivo human tissues. This
review emphasizes the newer techniques of SOCT and molecular imaging OCT, which
show excellent potential for clinical application but have yet to be well
reviewed in the literature. SOCT elucidates tissue characteristics, such as
oxygenation and carcinogenesis, by detecting wavelength-dependent absorption and
scattering of light in tissues. While SOCT measures endogenous biochemical
distributions, molecular imaging OCT detects exogenous molecular contrast agents.
These newer advances in functional OCT broaden the potential clinical application
of OCT by providing novel ways to understand tissue activity that cannot be
accomplished by other current imaging methodologies.