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10.3390/ijms19061738 http://scihub22266oqcxt.onion/10.3390/ijms19061738 C6032173!6032173 !29895749     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29895749 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2018 ; 19 (6 ): ä Nephropedia Template TP {{tp|p=29895749 |t=2018. Functional Regulation of PPARs through Post-Translational Modifications |pdf=|usr=}}{{29895749 }} gab.com Text Functional Regulation of PPARs through Post-Translational Modifications JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29895749 #FOAvip Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily and they are essential regulators of cell differentiation, tissue development, and energy metabolism. Given their central roles in sensing the cellular metabolic state and controlling metabolic homeostasis, PPARs became important targets of drug development for the management of metabolic disorders. The function of PPARs is mainly regulated through ligand binding, which induces structural changes, further affecting the interactions with co-activators or co-repressors to stimulate or inhibit their functions. In addition, PPAR functions are also regulated by various Post-translational modifications (PTMs). These PTMs include phosphorylation, SUMOylation, ubiquitination, acetylation, and O-GlcNAcylation, which are found at numerous modification sites. The addition of these PTMs has a wide spectrum of consequences on protein stability, transactivation function, and co-factor interaction. Moreover, certain PTMs in PPAR proteins have been associated with the status of metabolic diseases. In this review, we summarize the PTMs found on the three PPAR isoforms PPAR?, PPAR?/?, and PPAR?, and their corresponding modifying enzymes. We also discuss the functional roles of these PTMs in regulating metabolic homeostasis and provide a perspective for future research in this intriguing field. Twit Text FOAVip Functional Regulation of PPARs through Post-Translational Modifications ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29895749 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29895749 #FOAvip English Wikipedia <ref>{{Cite pmid|29895749 }}</ref> Functional Regulation of PPARs through Post-Translational Modifications #MMPMID29895749 Brunmeir R ; Xu F Int J Mol Sci 2018[Jun]; 19 (6 ): ä PMID29895749 show ga Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily and they are essential regulators of cell differentiation, tissue development, and energy metabolism. Given their central roles in sensing the cellular metabolic state and controlling metabolic homeostasis, PPARs became important targets of drug development for the management of metabolic disorders. The function of PPARs is mainly regulated through ligand binding, which induces structural changes, further affecting the interactions with co-activators or co-repressors to stimulate or inhibit their functions. In addition, PPAR functions are also regulated by various Post-translational modifications (PTMs). These PTMs include phosphorylation, SUMOylation, ubiquitination, acetylation, and O-GlcNAcylation, which are found at numerous modification sites. The addition of these PTMs has a wide spectrum of consequences on protein stability, transactivation function, and co-factor interaction. Moreover, certain PTMs in PPAR proteins have been associated with the status of metabolic diseases. In this review, we summarize the PTMs found on the three PPAR isoforms PPAR?, PPAR?/?, and PPAR?, and their corresponding modifying enzymes. We also discuss the functional roles of these PTMs in regulating metabolic homeostasis and provide a perspective for future research in this intriguing field. |Animals [MESH] |Humans [MESH] |PPAR alpha/genetics/metabolism [MESH] |PPAR delta/genetics/metabolism [MESH] |PPAR gamma/genetics/metabolism [MESH] |PPAR-beta/genetics/metabolism [MESH] |Peroxisome Proliferator-Activated Receptors/genetics/*metabolism [MESH] |Protein Processing, Post-Translational/genetics/physiology [MESH]Functional Regulation of PPARs through Post-Translational Modification(epmc).pdf DeepDyve Pubget Overpricing