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2018 ; 21
(Suppl 1
): S51-S56
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Functional Neuroimaging in Trigeminal Autonomic Cephalalgias
#MMPMID29720819
Obermann M
; Holle D
; Nagel S
Ann Indian Acad Neurol
2018[Apr]; 21
(Suppl 1
): S51-S56
PMID29720819
show ga
Functional neuroimaging was able to identify key structures for the
pathophysiology of trigeminal autonomic cephalalgias (TACs) including cluster
headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform
headache attacks with conjunctival injection and tearing or cranial autonomic
features and hemicrania continua. The posterior hypothalamus was the structure
most consistently depicted with functional imaging in different states of disease
with and without pain. Network-oriented imaging techniques such as resting-state
functional resonance imaging were able to show a broader involvement of human
trigeminal pain processing in the underlying pathophysiological mechanisms of the
different TACs, highlighting similarities between this distinct group of primary
headache disorders, while also demonstrating the differences in brain activation
across these disorders. The most important clinical assignment for neuroimaging
research from the treating physician remains the objective and reliable
distinction of each individual TAC syndrome from one another, to make the correct
clinical diagnosis as the foundation for proper treatment. More research will be
necessary to fulfill this unmet need.