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10.3390/biom5031580 http://scihub22266oqcxt.onion/10.3390/biom5031580 C4598765!4598765 !26197342     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26197342 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomolecules 2015 ; 5 (3 ): 1580-99 Nephropedia Template TP {{tp|p=26197342 |t=2015. Functional Integration of mRNA Translational Control Programs |pdf=|usr=}}{{26197342 }} gab.com Text Functional Integration of mRNA Translational Control Programs JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26197342 #FOAvip Regulated mRNA translation plays a key role in control of cell cycle progression in a variety of physiological and pathological processes, including in the self-renewal and survival of stem cells and cancer stem cells. While targeting mRNA translation presents an attractive strategy for control of aberrant cell cycle progression, mRNA translation is an underdeveloped therapeutic target. Regulated mRNAs are typically controlled through interaction with multiple RNA binding proteins (RBPs) but the mechanisms by which the functions of distinct RBPs bound to a common target mRNA are coordinated are poorly understood. The challenge now is to gain insight into these mechanisms of coordination and to identify the molecular mediators that integrate multiple, often conflicting, inputs. A first step includes the identification of altered mRNA ribonucleoprotein complex components that assemble on mRNAs bound by multiple, distinct RBPs compared to those recruited by individual RBPs. This review builds upon our knowledge of combinatorial control of mRNA translation during the maturation of oocytes from Xenopus laevis, to address molecular strategies that may mediate RBP diplomacy and conflict resolution for coordinated control of mRNA translational output. Continued study of regulated ribonucleoprotein complex dynamics promises valuable new insights into mRNA translational control and may suggest novel therapeutic strategies for the treatment of disease. Twit Text FOAVip Functional Integration of mRNA Translational Control Programs ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26197342 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26197342 #FOAvip English Wikipedia <ref>{{Cite pmid|26197342 }}</ref> Functional Integration of mRNA Translational Control Programs #MMPMID26197342 MacNicol MC ; Cragle CE ; Arumugam K ; Fosso B ; Pesole G ; MacNicol AM Biomolecules 2015[Jul]; 5 (3 ): 1580-99 PMID26197342 show ga Regulated mRNA translation plays a key role in control of cell cycle progression in a variety of physiological and pathological processes, including in the self-renewal and survival of stem cells and cancer stem cells. While targeting mRNA translation presents an attractive strategy for control of aberrant cell cycle progression, mRNA translation is an underdeveloped therapeutic target. Regulated mRNAs are typically controlled through interaction with multiple RNA binding proteins (RBPs) but the mechanisms by which the functions of distinct RBPs bound to a common target mRNA are coordinated are poorly understood. The challenge now is to gain insight into these mechanisms of coordination and to identify the molecular mediators that integrate multiple, often conflicting, inputs. A first step includes the identification of altered mRNA ribonucleoprotein complex components that assemble on mRNAs bound by multiple, distinct RBPs compared to those recruited by individual RBPs. This review builds upon our knowledge of combinatorial control of mRNA translation during the maturation of oocytes from Xenopus laevis, to address molecular strategies that may mediate RBP diplomacy and conflict resolution for coordinated control of mRNA translational output. Continued study of regulated ribonucleoprotein complex dynamics promises valuable new insights into mRNA translational control and may suggest novel therapeutic strategies for the treatment of disease. |*Protein Biosynthesis [MESH] |Animals [MESH] |Cell Cycle [MESH] |Humans [MESH] |Molecular Targeted Therapy [MESH]Functional Integration of mRNA Translational Control Programs (epmc).pdf DeepDyve Pubget Overpricing