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10.5009/gnl16055

http://scihub22266oqcxt.onion/10.5009/gnl16055
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suck abstract from ncbi


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pmid28452210
      Gut+Liver 2017 ; 11 (3 ): 349-357
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  • Functional Dyspepsia: Advances in Diagnosis and Therapy #MMPMID28452210
  • Talley NJ
  • Gut Liver 2017[May]; 11 (3 ): 349-357 PMID28452210 show ga
  • Functional dyspepsia (FD) is a common but under-recognized syndrome comprising bothersome recurrent postprandial fullness, early satiety, or epigastric pain/burning. Epidemiologically, there are two clinically distinct FD syndromes (although these often overlap clinically): postprandial distress syndrome (PDS; comprising early satiety or meal-related fullness) and epigastric pain syndrome. Symptoms of gastroesophageal reflux disease overlap with FD more than expected by chance; a subset has pathological acid reflux. The pretest probability of FD in a patient who presents with classical FD symptoms and no alarm features is high, approximately 0.7. Coexistent heartburn should not lead to the exclusion of FD as a diagnosis. One of the most exciting observations in FD has been the consistent finding of increased duodenal eosinophilia, notably in PDS. Small bowel homing T cells, signaling intestinal inflammation, and increased cytokines have been detected in the circulation, and elevated tumor necrosis factor-? levels have been significantly correlated with increased anxiety. Postinfectious gastroenteritis is a risk factor for FD. Therapeutic options remain limited and provide only symptomatic benefit in most cases. Only one therapy is known to change the natural history of FD-Helicobacter pylori eradication. Treatment of duodenal eosinophilia is under investigation.
  • |*Postprandial Period [MESH]
  • |*Symptom Assessment [MESH]
  • |Diagnosis, Differential [MESH]
  • |Duodenal Diseases/complications/diagnosis [MESH]
  • |Dyspepsia/*diagnosis/etiology/*therapy [MESH]
  • |Eosinophilia/complications/diagnosis [MESH]
  • |Gastroesophageal Reflux/complications/diagnosis [MESH]
  • |Heartburn/complications/diagnosis [MESH]
  • |Helicobacter Infections/complications/drug therapy [MESH]
  • |Helicobacter pylori [MESH]


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