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10.1021/acsabm.4c00147 http://scihub22266oqcxt.onion/10.1021/acsabm.4c00147 38754861!ä!38754861 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Appl+Bio+Mater 2024 ; ä (ä): ä Nephropedia Template TP {{tp|p=38754861|t=2024. Fully Biodegradable Elastomer-Based Device for Oral Macromolecule Delivery |pdf=|usr=}}{{38754861}} gab.com Text Fully Biodegradable Elastomer-Based Device for Oral Macromolecule Delivery JO: ACS Appl Bio Mater http://www.kidney.de/pget.php?&tw=1&pmid=38754861 #FOAvip Oral devices, such as foil-type devices, show great potential for the delivery of poorly permeable macromolecules by enabling unidirectional release of the loaded pharmaceutical composition in close proximity to the epithelium in the small intestine or colon. However, one of the primary concerns associated with the use of foil-type devices so far has been the utilization of nonbiodegradable elastomers in the fabrication of the devices. Therefore, research into biodegradable substitute materials with similar characteristics enables drug delivery in a sustainable and environmentally friendly manner. In this study, a biodegradable elastomer, polyoctanediol citrate (POC), was synthesized via a one-pot reaction, with subsequent purification and microscale pattern replication via casting. The microstructure geometry was designed to enable fabrication of foil-type devices with the selected elastomer, which has a high intrinsic surface free energy. The final elastomer was demonstrated to have an elastic modulus ranging up to 2.2 +/- 0.1 MPa, with strain at failure up to 110.1 +/- 1.5%. Devices were loaded with acetaminophen and enterically coated, demonstrating 100% release at 2.5 h, following dissolution for 1 h in 0.1 M hydrochloric acid and 1.5 h in pH 6.8 phosphate-buffered saline. The elastomer demonstrated promising properties based on mechanical testing, surface free energy evaluation, and degradation studies. Twit Text FOAVip Fully Biodegradable Elastomer-Based Device for Oral Macromolecule Delivery ????ACS Appl Bio Mater http://www.kidney.de/pget.php?&tw=1&pmid=38754861 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=38754861 #FOAvip English Wikipedia <ref>{{Cite pmid|38754861}}</ref> Fully Biodegradable Elastomer-Based Device for Oral Macromolecule Delivery #MMPMID38754861 McCabe R; Eklund Thamdrup LH; Ghavami M; Boisen A ACS Appl Bio Mater 2024[May]; ä (ä): ä PMID38754861show ga Oral devices, such as foil-type devices, show great potential for the delivery of poorly permeable macromolecules by enabling unidirectional release of the loaded pharmaceutical composition in close proximity to the epithelium in the small intestine or colon. However, one of the primary concerns associated with the use of foil-type devices so far has been the utilization of nonbiodegradable elastomers in the fabrication of the devices. Therefore, research into biodegradable substitute materials with similar characteristics enables drug delivery in a sustainable and environmentally friendly manner. In this study, a biodegradable elastomer, polyoctanediol citrate (POC), was synthesized via a one-pot reaction, with subsequent purification and microscale pattern replication via casting. The microstructure geometry was designed to enable fabrication of foil-type devices with the selected elastomer, which has a high intrinsic surface free energy. The final elastomer was demonstrated to have an elastic modulus ranging up to 2.2 +/- 0.1 MPa, with strain at failure up to 110.1 +/- 1.5%. Devices were loaded with acetaminophen and enterically coated, demonstrating 100% release at 2.5 h, following dissolution for 1 h in 0.1 M hydrochloric acid and 1.5 h in pH 6.8 phosphate-buffered saline. The elastomer demonstrated promising properties based on mechanical testing, surface free energy evaluation, and degradation studies. äFully Biodegradable Elastomer-Based Device for Oral Macromolecule Deli(epmc).pdf DeepDyve Pubget Overpricing