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Frontotemporal dementia: diagnosis, deficits and management
#MMPMID25531687
Bott NT
; Radke A
; Stephens ML
; Kramer JH
Neurodegener Dis Manag
2014[]; 4
(6
): 439-54
PMID25531687
show ga
Frontotemporal dementia (FTD) is a progressive neurologic syndrome with diverse
clinical presentations and attendant underlying pathologies. Psychiatric
prodrome, neuropsychiatric symptoms and language difficulties are common in FTD,
but the diversity of presentation raises unique diagnostic challenges that can
significantly impact patient care and counsel for caregivers regarding clinical
status and prognosis. While neuropsychiatric symptom measures are helpful, more
sensitive assessments delineating the specific behavioral and linguistic deficits
accompanying FTD are needed. Comprehensive clinical assessment in combination
with evaluation of language, socio-emotional functioning, cognition and
neuroimaging aid in accurate and early diagnosis and treatment planning. In what
follows, we review each of the FTD syndromes, highlight current research
investigating the cognitive, behavioral and socio-emotional deficits observed
with this disease, address common diagnostic challenges and summarize best
practices associated with management of FTD.
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