Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29564205
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Transplant+Rep
2018 ; 5
(1
): 72-81
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
From "Gut Feeling" to Objectivity: Machine Preservation of the Liver as a Tool to
Assess Organ Viability
#MMPMID29564205
Watson CJE
; Jochmans I
Curr Transplant Rep
2018[]; 5
(1
): 72-81
PMID29564205
show ga
PURPOSE OF REVIEW: The purpose of this review was to summarise how machine
perfusion could contribute to viability assessment of donor livers. RECENT
FINDINGS: In both hypothermic and normothermic machine perfusion, perfusate
transaminase measurement has allowed pretransplant assessment of hepatocellular
damage. Hypothermic perfusion permits transplantation of marginal grafts but as
yet has not permitted formal viability assessment. Livers undergoing normothermic
perfusion have been investigated using parameters similar to those used to
evaluate the liver in vivo. Lactate clearance, glucose evolution and pH
regulation during normothermic perfusion seem promising measures of viability. In
addition, bile chemistry might inform on cholangiocyte viability and the
likelihood of post-transplant cholangiopathy. SUMMARY: While the use of machine
perfusion technology has the potential to reduce and even remove uncertainty
regarding liver graft viability, analysis of large datasets, such as those
derived from large multicenter trials of machine perfusion, are needed to provide
sufficient information to enable viability parameters to be defined and validated
.