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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nat+Neurosci
2015 ; 18
(4
): 576-81
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Frequency-specific hippocampal-prefrontal interactions during associative
learning
#MMPMID25706471
Brincat SL
; Miller EK
Nat Neurosci
2015[Apr]; 18
(4
): 576-81
PMID25706471
show ga
Much of our knowledge of the world depends on learning associations (for example,
face-name), for which the hippocampus (HPC) and prefrontal cortex (PFC) are
critical. HPC-PFC interactions have rarely been studied in monkeys, whose
cognitive and mnemonic abilities are akin to those of humans. We found functional
differences and frequency-specific interactions between HPC and PFC of monkeys
learning object pair associations, an animal model of human explicit memory. PFC
spiking activity reflected learning in parallel with behavioral performance,
whereas HPC neurons reflected feedback about whether trial-and-error guesses were
correct or incorrect. Theta-band HPC-PFC synchrony was stronger after errors, was
driven primarily by PFC to HPC directional influences and decreased with
learning. In contrast, alpha/beta-band synchrony was stronger after correct
trials, was driven more by HPC and increased with learning. Rapid object
associative learning may occur in PFC, whereas HPC may guide neocortical
plasticity by signaling success or failure via oscillatory synchrony in different
frequency bands.