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10.1186/s11658-016-0028-7 http://scihub22266oqcxt.onion/10.1186/s11658-016-0028-7 C5415767!5415767 !28536630     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28536630 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Mol+Biol+Lett 2016 ; 21 (ä): 28 Nephropedia Template TP {{tp|p=28536630 |t=2016. Framework to function: mechanosensitive regulators of gene transcription |pdf=|usr=}}{{28536630 }} gab.com Text Framework to function: mechanosensitive regulators of gene transcription JO: Cell Mol Biol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28536630 #FOAvip Mechanobiology has shifted our understanding of fundamental cellular and physiological functions. Changes to the stiffness of the extracellular matrix, cell rigidity, or shape of the cell environment were considered in the past to be a consequence of aging or pathological processes. We now understand that these factors can actually be causative biological mediators of cell growth to control organ size. Mechanical cues are known to trigger a relatively fast translocation of specific transcriptional co-factors such as MRTFs, YAP and TAZ from the cytoplasm to the cell nucleus to initiate discrete transcriptional programs. The focus of this review is the molecular mechanisms by which biophysical stimuli that induce changes in cytoplasmic actin dynamics are communicated within cells to elicit gene-specific transcription via nuclear localisation or activation of specialized transcription factors, namely MRTFs and the Hippo pathway effectors YAP and TAZ. We propose here that MRTFs, YAP and TAZ closely collaborate as mechano-effectors. Twit Text FOAVip Framework to function: mechanosensitive regulators of gene transcription ????Cell Mol Biol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28536630 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28536630 #FOAvip English Wikipedia <ref>{{Cite pmid|28536630 }}</ref> Framework to function: mechanosensitive regulators of gene transcription #MMPMID28536630 Finch-Edmondson M ; Sudol M Cell Mol Biol Lett 2016[]; 21 (ä): 28 PMID28536630 show ga Mechanobiology has shifted our understanding of fundamental cellular and physiological functions. Changes to the stiffness of the extracellular matrix, cell rigidity, or shape of the cell environment were considered in the past to be a consequence of aging or pathological processes. We now understand that these factors can actually be causative biological mediators of cell growth to control organ size. Mechanical cues are known to trigger a relatively fast translocation of specific transcriptional co-factors such as MRTFs, YAP and TAZ from the cytoplasm to the cell nucleus to initiate discrete transcriptional programs. The focus of this review is the molecular mechanisms by which biophysical stimuli that induce changes in cytoplasmic actin dynamics are communicated within cells to elicit gene-specific transcription via nuclear localisation or activation of specialized transcription factors, namely MRTFs and the Hippo pathway effectors YAP and TAZ. We propose here that MRTFs, YAP and TAZ closely collaborate as mechano-effectors. |*Mechanotransduction, Cellular [MESH] |*Transcription, Genetic [MESH] |Actins [MESH] |Animals [MESH] |Epithelial-Mesenchymal Transition [MESH] |Humans [MESH] |Nuclear Proteins [MESH] |Trans-Activators [MESH]Framework to function: mechanosensitive regulators of gene transcripti(epmc).pdf DeepDyve Pubget Overpricing