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2017 ; 12
(ä): 1193-1198
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Frailty syndrome in ambulatory patients with COPD
#MMPMID28458530
Limpawattana P
; Putraveephong S
; Inthasuwan P
; Boonsawat W
; Theerakulpisut D
; Chindaprasirt J
Int J Chron Obstruct Pulmon Dis
2017[]; 12
(ä): 1193-1198
PMID28458530
show ga
Frailty is a state of increased risk of unfavorable outcomes when exposed to
stressors, and COPD is one of the several chronic illnesses associated with the
condition. However, few studies have been conducted regarding the prevalence of
COPD and its related factors in Southeast Asia. The objectives of this study were
to determine the prevalence of frailty in COPD patients and to identify the
associated factors in these populations. A cross-sectional study of COPD patients
who attended a COPD clinic was conducted from May 2015 to December 2016. Baseline
characteristics were collected, and the diagnosis of frailty was based on the
FRAIL (fatigue, resistance, ambulation, illnesses, and loss of weight) scale.
Descriptive statistics were used to analyze baseline data. Factors associated
with frailty were analyzed using univariate and multivariate regression analyses.
The results showed that the prevalence rates of frailty and pre-frailty were 6.6%
(eight out of 121 cases) and 41.3% (50 out of 121 cases), respectively, among
COPD patients. Fatigue was the most common component of the FRAIL scale that was
found more frequently in frail patients than in non-frail patients (odds ratio
[OR] 91.9). Factors associated with frailty according to multivariate analyses
were comorbid cancer (adjusted OR [AOR] 45.8), at least two instances of
nonelective admission over the past 12 months (AOR 112.5), high waist
circumference (WC) (AOR 1.3), and presence of sarcopenia (AOR 29.5). In
conclusion, frailty affected 6.6% of stable COPD patients. Cancer, two or more
instances of nonelective hospitalization over the past 12 months, high WC, and
presence of sarcopenia were associated with frailty. Early identification and
intervention in high-risk patients is recommended to prevent or delay the adverse
outcomes of frailty.
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