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2015 ; 8
(3
): 2771-8
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FoxM1 influences mouse hepatocellular carcinoma metastasis in vitro
#MMPMID26045783
Zhang N
; Xie Y
; Li B
; Ning Z
; Wang A
; Cui X
Int J Clin Exp Pathol
2015[]; 8
(3
): 2771-8
PMID26045783
show ga
Lymph node metastasis is recognized as an important mode of liver cancer
metastasis. Two hepatocarcinoma cell lines, Hca-F get high (75%) and Hca-P get
low (25%) incidences of lymph node metastasis. Forkhead box M1 (FoxM1) is
described as a major oncogenic transcription factor in tumor initiation,
promotion, and progression. Ezrin is linked to aggressive tumor behavior by
involving all stages of tumor metastasis. We firstly compared the expression of
FoxM1 and Ezrin between two cells. Then we transiently transfected Hca-P cells
with over-FoxM1 plasmid and Hca-F cells with sh-FoxM1 plasmid. We found that both
FoxM1 and Ezrin expressed higher in Hca-F than Hca-P. We successfully
down-regulated or up-regulated FoxM1 expression in Hca-F or Hca-P cells. And we
found that FoxM1 had correlation with proliferation, invasion and migration in
mouse hepatocellular carcinoma cell lines.